AbstractRapid urbanization and natural hazards are posing threats to local ecological processes and ecosystem services worldwide. Using land use, socioeconomic, and natural hazards data, we conducted an assessment of the ecological vulnerability of prefectures in Sichuan Province for the years 2005, 2010, and 2015 to capture variations in its capacity to modulate in response to disturbances and to explore potential factors driving these variations. We selected five landscape metrics and two topological indicators for the proposed ecological vulnerability index (EVI), and constructed the EVI using a principal component analysis-based entropy method. A series of correlation analyses were subsequently performed to identify the factors driving variations in ecological vulnerability. The results show that: (1) for each of the study years, prefectures with high ecological vulnerability were located mainly in southern and eastern Sichuan, whereas prefectures in central and western Sichuan were of relatively low ecological vulnerability; (2) Sichuan’s ecological vulnerability increased significantly (p = 0.011) during 2005–2010; (3) anthropogenic activities were the main factors driving variations in ecological vulnerability. These findings provide a scientific basis for implementing ecological protection and restoration in Sichuan as well as guidelines for achieving integrated disaster risk reduction.