Abstract Metabolic syndrome is defined as a constellation of many metabolic disorders such as hypertension, impaired glucose tolerance, dyslipidemia and obesity, being this last disorder a key factor in the etiology of the syndrome. Animal model of metabolic syndrome allows us to study the phenomenology of disorders of cooperative interactions of effector cells responsible for regulating of the blood vessels tone. Here, we have characterized the metabolic, vascular changes in male Wistar rats fed on a high-fat, high-carbohydrate diet including lard (17%), fructose (17%) together with 20% fructose in drinking water, control rats were fed a standard rat chow. During 12 weeks on this diet, rats showed a change in body weight with impaired glucose tolerance. Vascular disorders included endothelial dysfunction in pulmonary artery.