Published in
Rockefeller University Press, Journal of Experimental Medicine, 11(217), 2020
DOI: 10.1084/jem.20200684
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β-Catenin regulates tumor-derived PD-L1
Journal article published in 2020 by
Chuanhui Han,
Yang-Xin Fu 
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Abstract
In this issue of JEM, Du et al. (https://doi.org/10.1084/jem.20191115) report that enhancement of the β-catenin signaling by Wnt or EGF treatment increases the expression of PD-L1 in an AKT and β-catenin–dependent manner, and blocking the AKT pathway synergizes with anti–PD-1 in a glioblastoma model.