Evaluating climate change impacts and the suitability of potential land resources is crucial for sustainable irrigated agricultural systems. This study applied a multi-criteria analysis supported by the Geographic Information System (GIS) application to produce irrigation suitability maps for the Anger River basin’s (Ethiopia) irrigation command area to optimize its irrigation system. Six irrigation suitability factors, such as distance to water sources (rivers), slope, land use/land cover, soil texture, drainage, and depth, including climate change impacts, were used. These factors were spatially analyzed using a comparison matrix and overlying the factors with 30 m resolutions to estimate the potential irrigable area. About 40% of the study area was classified as moderately to highly suitable for surface water irrigation systems. Moreover, we found that a large proportion of the study area is suitable for surface irrigation system, suggesting the relevance of implementing an enhanced irrigation system for improving the surface irrigation water productivity of the basin. However, future climate change is predicted to negatively affect the irrigation suitable area due to water scarcity. Therefore, this study provides useful information on the irrigation suitability and potential of the study area that could be used to facilitate the water resource development and food security plans.