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Elsevier, Toxicon: An Interdisciplinary Journal on the Toxins Derived from Animals, Plants and Microorganisms, 2-3(55), p. 633-637, 2010

DOI: 10.1016/j.toxicon.2009.07.016

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Evidence of okadaic acid production in a cultured strain of the marine dinoflagellate Prorocentrum rhathymum from Malaysia

Journal article published in 2010 by Amandine Caillaud ORCID, Pablo de la Iglesia, Mònica Campàs ORCID, Laurence M. Elandaloussi, M. Fernández, Normawaty Mohamad Noor, Karl B. Andree, Jorge Diogène ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Protein phosphatase inhibition assay (PPIA), Neuroblastoma cell-based assay (Neuro-2a CBA) and LC-MS/MS analysis revealed for the first time the production of okadaic acid (OA) by a Prorocentrum rhathymum strain. Low amounts of OA were detected by LC-MS/MS analysis. Inhibition of PP2A activity and a weak toxicity to the Neuro-2a CBA were also observed.