Published in
Advances in Laboratory Medicine / Avances en Medicina de Laboratorio, 0(0), 2020
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Big data and reference intervals: rationale, current practices, harmonization and standardization prerequisites and future perspectives of indirect determination of reference intervals using routine data
Journal article published in 2020 by
Luisa Martinez-Sanchez 
,
Fernando Marques-Garcia,
Yesim Ozarda,
Albert Blanco,
Nannette Brouwer,
Francesca Canalias,
Christa Cobbaert,
Marc Thelen,
Wendy den Elzen
,
Fernando Marques-Garcia,
Yesim Ozarda,
Albert Blanco,
Nannette Brouwer,
Francesca Canalias,
Christa Cobbaert,
Marc Thelen,
Wendy den Elzen
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Abstract
AbstractReference intervals are commonly used as a decision-making tool. In this review, we provide an overview on “big data” and reference intervals, describing the rationale, current practices including statistical methods, essential prerequisites concerning data quality, including harmonization and standardization, and future perspectives of the indirect determination of reference intervals using routine laboratory data.