Published in

American Society for Microbiology, mBio, 4(11), 2020

DOI: 10.1128/mbio.01816-20

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Signaling Pathways Governing the Caspofungin Paradoxical Effect in Aspergillus fumigatus

Journal article published in 2020 by Nicolas Papon ORCID, Florent Morio ORCID, Dominique Sanglard ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Aspergillus fumigatus is responsible for a wide range of diseases affecting several million people worldwide. Currently, a few families of antifungals are available to fight aspergillosis, and we are facing a worrisome increase in resistance to azoles, the drugs used for both first-line treatment and prophylaxis of invasive aspergillosis. In this context, some of the latest antifungals, i.e., echinocandins, have gained attention. Even though acquired resistance to echinocandins is yet uncommon in A. fumigatus clinical isolates, some strains exhibit another characteristic that relies on their capacity to grow at suprainhibitory echinocandin concentrations in vitro .