Morocco is considered one of the most threatened countries by climate change. Over the last century, oases ecosystems in this country showed a high vulnerability to climate variation, which has led to water scarcity, an increase in land salinity, and therefore, a decrease in agricultural production. Conscious of these issues, several solutions are initiated by the government to cope with climate change adverse effects. Many programs of rehabilitation were launched, and advanced researches are in progress in order to use some biofertilizers to improve tolerance of oasis crops to drought and salinity toward sustainable agriculture. The aim of this chapter is to give an overview of the impacts of climate change on oasis agriculture in Morocco and to provide potentially effective strategies to promote oasis agriculture under climate change. As a conclusion, the authors found that the use of different biofertilizers could be a potential strategy to mitigate climate change effects on oasis agriculture in Morocco.