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Springer, Infection, 1(49), p. 171-175, 2020

DOI: 10.1007/s15010-020-01497-2

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Diagnosis of COVID-19 using multiple antibody assays in two cases with negative PCR results from nasopharyngeal swabs

Journal article published in 2020 by Marianna Theresia Traugott, Wolfgang Hoepler ORCID, Tamara Seitz, Sebastian Baumgartner, Mario Karolyi ORCID, Erich Pawelka, Emanuela Friese, Stephanie Neuhold, Hasan Kelani, Florian Thalhammer, Alexander Zoufaly, Hermann Laferl, Judith Helene Aberle, Christoph Wenisch, Elisabeth Puchhammer-Stöckl and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

AbstractWe report of two cases of progressed COVID-19 with negative PCR tests from nasopharyngeal swabs, in whom diagnosis was made by different antibody assays, including a lateral flow rapid test and multiple commercial ELISAs, finally confirmed by comprehensive serological assays. These cases highlight that commercial ELISAs and even rapid tests might significantly aid the diagnosis of COVID-19, particularly, if a combination of serological assays is used with a specific clinical question, in severely ill patients after seroconversion and when comprehensive serological methods are used for confirmation.