Published in
American Association for the Advancement of Science, Science Signaling, 644(13), 2020
DOI: 10.1126/scisignal.abb4749
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Targeting the kinase insert loop of PERK selectively modulates PERK signaling without systemic toxicity in mice
Journal article published in 2020 by
Daniel T. Hughes 
,
Mark Halliday,
Heather L. Smith,
Nicholas C. Verity,
Colin Molloy ,
Helois Radford ,
Adrian J. Butcher,
Giovanna R. Mallucci
,
Mark Halliday,
Heather L. Smith,
Nicholas C. Verity,
Colin Molloy ,
Helois Radford ,
Adrian J. Butcher,
Giovanna R. Mallucci
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Abstract
Targeting a phosphosite in the kinase PERK may protect neurons and avoid toxicity in prion disease.