OBJECTIVE: Our study aimed to compare between quantum movement technique (QMT) and William flexion exercise (WFE) in patients with low back pain (LBP) based on pain and walking ability. METHODS: Six-session QMT and WFE were provided for two groups of participants. The frequency of intervention was 6 times/week. Twenty patients (aged 25–65 years) with LBP were randomly assigned into the QMT group (n = 10) or the WFE group (n = 10). The primary outcome of the intervention was pain, measured using the numeric pain rating scale, while the secondary outcome was walking ability, measured using the Oswestry Disability Index. The measurements were conducted at baseline and the end of the intervention. RESULTS: Pain reduction was significantly shown in both groups (p < 0.05). However, QMT was shown more effective in reducing pain compared to WFE (p < 0.05). In addition, we found the significant improvement of walking ability in both groups following the intervention (p < 0.05), but no significant difference was shown between two groups (p > 0.05). CONCLUSIONS: QMT is more effective than WFE for reducing pain in patients with LBP.