Published in
American Physiological Society, Journal of Applied Physiology, 4(129), p. 837-845, 2020
DOI: 10.1152/japplphysiol.00097.2020
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The proteomic response is linked to regional lung volumes in ventilator-induced lung injury
Journal article published in 2020 by
Seiha Yen 
,
Yong Song ,
Melissa Preissner,
Ellen Bennett ,
Richard Wilson,
Macarena Pavez,
Stephen Dubsky,
Peter A. Dargaville,
Andreas Fouras,
Graeme R. Zosky
,
Yong Song ,
Melissa Preissner,
Ellen Bennett ,
Richard Wilson,
Macarena Pavez,
Stephen Dubsky,
Peter A. Dargaville,
Andreas Fouras,
Graeme R. Zosky
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Abstract
This study provides novel insights into the regional response to mechanical ventilation in the setting of acid-induced lung injury and highlights the complex interaction between tidal stretch and low end-expiratory lung volumes; both of which caused altered regulation of different injury pathways.