Published in
European Centre for Disease Prevention and Control, Eurosurveillance, 31(25), 2020
DOI: 10.2807/1560-7917.es.2020.25.31.2001383
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Age-specific SARS-CoV-2 infection fatality ratio and associated risk factors, Italy, February to April 2020
,
Marcello Tirani,
Danilo Cereda,
Filippo Trentini,
Giorgio Guzzetta,
Valentina Marziano,
Sabrina Buoro,
Simona Riboli,
Lucia Crottogini,
Raffaella Piccarreta,
Alessandra Piatti,
Giacomo Grasselli,
Alessia Melegaro,
Maria Gramegna,
Marco Ajelli
and other authors.
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Abstract
We analysed 5,484 close contacts of coronavirus disease (COVID-19) cases in Italy, all tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Infection fatality ratio was 0.43% (95% confidence interval (CI): 0.21–0.79) for individuals younger than 70 years and 10.5% (95% CI: 8.0–13.6) for older individuals. Risk of death after infection was 62% lower (95% CI: 31–80) in clusters identified after 16 March 2020 and 1.8-fold higher for males (95% CI: 1.03–3.16).