Published in
American Association for the Advancement of Science, Science Translational Medicine, 557(12), 2020
DOI: 10.1126/scitranslmed.abc5332
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3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoV-infected mice
Journal article published in 2020 by
Athri D. Rathnayake 
,
Jian Zheng ,
Yunjeong Kim ,
Krishani Dinali Perera ,
Samantha Mackin ,
David K. Meyerholz ,
Maithri M. Kashipathy ,
Kevin P. Battaile ,
Scott Lovell ,
Stanley Perlman ,
William C. Groutas ,
Kyeong-Ok Chang
,
Jian Zheng ,
Yunjeong Kim ,
Krishani Dinali Perera ,
Samantha Mackin ,
David K. Meyerholz ,
Maithri M. Kashipathy ,
Kevin P. Battaile ,
Scott Lovell ,
Stanley Perlman ,
William C. Groutas ,
Kyeong-Ok Chang
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Abstract
Optimized small-molecule 3C-like protease inhibitors show potency against human coronaviruses in both cell culture and a mouse model.