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Sociedade Brasileira de Medicina Tropical - SBMT, Revista da Sociedade Brasileira de Medicina Tropical, 4(46), p. 525-527, 2013

DOI: 10.1590/0037-8682-0098-2013

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Possible artemisinin-based combination therapy-resistant malaria in Nigeria: a report of three cases

Journal article published in 2013 by Nnennaya Anthony Ajayi, Ajayi,Nnennaya Anthony, Ukwaja,Kingsley Nnanna, Kingsley Nnanna Ukwaja ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Artemisinin-based combination therapy-resistant malaria is rare in Sub-Saharan Africa. The World Health Organization identifies monitoring and surveillance using day-3 parasitaemia post-treatment as the standard test for identifying suspected artemisinin resistance. We report three cases of early treatment failure due to possible artemisinin-based combination therapy-resistant Plasmodium falciparum malaria. All cases showed adequate clinical and parasitological responses to quinine. This study reveals a need to re-evaluate the quality and efficacy of artemisinin-based combination therapy agents in Nigeria and Sub-Saharan Africa.