Abstract In extensions of two Higgs doublet models with vectorlike quarks, the decays of vectorlike quarks may easily be dominated by cascade decays through charged or neutral Higgs bosons leading to signatures with 6 top or bottom quarks. Since top quark decays also contain bottom quarks, a common signature for many possible decay chains is 6 bottom quarks in the final state. We present a search strategy focusing on this final state and find the mass ranges of vectorlike quarks and Higgs bosons that can be explored at the Large Hadron Collider. Among other results, the sensitivity to the charged and neutral Higgs bosons, extending to about 2 TeV, stands out when compared to models without vectorlike matter.