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Public Library of Science, PLoS ONE, 4(7), p. e34534, 2012

DOI: 10.1371/journal.pone.0034534

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MicroRNA Dysregulation in the Spinal Cord following Traumatic Injury

Journal article published in 2012 by Mónica Yunta, Manuel Nieto-Díaz ORCID, Francisco J. Esteban, Marcos Caballero-López, Rosa Navarro-Ruíz, David Reigada ORCID, D. Wolfgang Pita-Thomas, D. Wolfgang Pita Thomas, A. del Águila, Ángela del Águila, Teresa Muñoz-Galdeano, Rodrigo M. Maza
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Spinal cord injury (SCI) triggers a multitude of pathophysiological events that are tightly regulated by the expression levels of specific genes. Recent studies suggest that changes in gene expression following neural injury can result from the dysregulation of microRNAs, short non-coding RNA molecules that repress the translation of target mRNA. To understand the mechanisms underlying gene alterations following SCI, we analyzed the microRNA expression patterns at different time points following rat spinal cord injury.