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Springer Verlag, Lecture Notes in Computer Science, p. 31-45

DOI: 10.1007/978-3-642-02008-7_3

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Boosting Protein Threading Accuracy

Journal article published in 2009 by Jian Peng ORCID, Jinbo Xu
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Protein threading is one of the most successful protein structure prediction methods. Most protein threading methods use a scoring function linearly combining sequence and structure features to measure the quality of a sequence-template alignment so that a dynamic programming algorithm can be used to optimize the scoring function. However, a linear scoring function cannot fully exploit interdependency among features and thus, limits alignment accuracy.