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Wiley, Journal of Surgical Oncology, 6(102), p. 689-698

DOI: 10.1002/jso.21665

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Atypical expression and distribution of embryonic stem cell marker, OCT4, in human lung adenocarcinoma

Journal article published in 2010 by Golnaz Karoubi, Lourdes Cortes-Dericks, Mathias Gugger, Domenico Galetta, Lorenzo Spaggiari, Ralph A. Schmid ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Lung cancer is one of the leading causes of cancer-related deaths in the world. Although the origin still remains to be resolved, a prevailing hypothesis implies the involvement of cancer stem cells (CSCs) responsible for tumor initiation, maintenance, and progression. Embryonic stem cell marker, OCT4, encoding the spliced variants OCT4A and OCT4B, has recently been shown to have a dual role; as a potential adult stem cell marker and as a CSC marker in germline and somatic tumors.