Published in
American Association for the Advancement of Science, Science Translational Medicine, 554(12), 2020
DOI: 10.1126/scitranslmed.aaw4974
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Cellular senescence impairs the reversibility of pulmonary arterial hypertension
Journal article published in 2020 by
Diederik E. van der Feen 
,
Guido P. L. Bossers,
Quint A. J. Hagdorn ,
Jan-Renier Moonen ,
Kondababu Kurakula,
Robert Szulcek ,
James Chappell ,
Francesco Vallania ,
Michele Donato,
Klaas Kok ,
Jaskaren S. Kohli,
Arjen H. Petersen,
Tom van Leusden,
Marco Demaria ,
Marie-José T. H. Goumans
and other authors.
,
Guido P. L. Bossers,
Quint A. J. Hagdorn ,
Jan-Renier Moonen ,
Kondababu Kurakula,
Robert Szulcek ,
James Chappell ,
Francesco Vallania ,
Michele Donato,
Klaas Kok ,
Jaskaren S. Kohli,
Arjen H. Petersen,
Tom van Leusden,
Marco Demaria ,
Marie-José T. H. Goumans
and other authors.
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Abstract
The transition from reversible to irreversible pulmonary arterial hypertension involves vascular senescence and can be countered by senolysis.