Published in
Facultad de Humanidades y Ciencias de la Educación, Synthesis: Journal of Synthetic Organic Chemistry, 2020
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Synthesis of Benzo-Fused 11H-Pyrido[2,1-b]quinazolin-11-ones by a Buchwald–Hartwig Coupling/Pyridine Dearomatization Sequence in Eucalyptol
Journal article published in 2020 by
Sabine Berteina-Raboin 
,
Joana F. Campos ,
Alexandra Pacheco-Benichou,
Corinne Fruit,
Thierry Besson
,
Joana F. Campos ,
Alexandra Pacheco-Benichou,
Corinne Fruit,
Thierry Besson
This paper is made freely available by the publisher.
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Abstract
The synthesis of a new library of polyheterocyclic 11H-pyrido[2,1-b]quinazolin-11-one derivatives was investigated. Satisfactory conditions were obtained via sequential C–N Buchwald–Hartwig coupling and pyridine dearomatization. In this work, traditional solvents were replaced by the bio-sourced eucalyptol, confirming the interest in it as a green solvent in chemistry.