The human microbiome undergoes variation in the most diverse regions of our body, according to the conditions to which it is exposed, being of vital importance for human health. It presents several conditions that can promote the establishment of microorganisms and in imbalance favor the development of opportunistic pathogens, the knowledge of the distribution of these microorganisms in different organs and their biological role leads to a better understanding of their complex dynamics, improving the development of a new one forms of diagnosis and even treatment of certain pathologies. Among the most pathologies studied today, we can mention infections caused by fungi is one of the widely studied area. These microorganisms are becoming increasingly resistant to conventional treatments, increasing reports of resistance, especially the Candida species, which despite being present in the normal flora of the human organism have been causing several cases of contamination and infections, called candidosis. Due to the increased resistance to conventional antifungal treatments, it is necessary to develop strategies that can prevent and treat the spread of these microorganisms. For this, alternative studies with medicinal plants have been growing and expanding the understanding and applicability of new compounds with antimicrobial properties, since, for millennia, makind has used plants to treat various types of diseases and this traditional knowledge facilitates the search for research targets of natural components from plants, allowing scientific proof of these therapeutic effects. This work aims at a bibliographical survey of the applicabilities of the Phyllanthus niruri L. (Stone-breaking) plant, in the face of the challenges of science when developing new sources to combat resistant microorganisms.