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American Physiological Society, Journal of Applied Physiology, 3(129), p. 442-448, 2020

DOI: 10.1152/japplphysiol.00828.2019

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Hypoglossal Nerve Stimulation in a Rabbit Model of Obstructive Sleep Apnea Reduces Apneas and Improves Oxygenation

Journal article published in 2020 by Matthew Schiefer, Jenniffer Gamble, Jonathan P. Baskin, Kingman P. Strohl ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

This report describes a rabbit model for testing the impact of hypoglossal nerve stimulation (HNS) on obstructive apneas. Obstructive sleep apnea (OSA) is induced by injecting hyaluronic acid (as a filler) into the base of the tongue. HNS reduced the length and rate of obstructions and improved oxygenation during sleep. Our efforts with this model advanced understanding of the complexities of this OSA preclinical model for neurostimulation reversal of sleep-disordered breathing.