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Future Medicine, Future Microbiology, 9(15), p. 739-752, 2020

DOI: 10.2217/fmb-2019-0246

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Rhizopus-host interplay of disseminated mucormycosis in immunocompetent mice

Journal article published in 2020 by Amanda R dos Santos ORCID, Amanda R. dos Santos ORCID, Thais F. Fraga-Silva ORCID, Débora de F. Almeida, Rodolfo F. dos Santos, Débora de F. Almeida, Angela C. Finato, Bárbara C. Amorim ORCID, Maria I. Andrade, Cleverson T. Soares ORCID, Vanessa S. Lara ORCID, Nara Lm Almeida ORCID, Olavo S. de Arruda, Maria Sp de Arruda ORCID, James Venturini ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Aim: To investigate the immune response of disseminated Ryzopus oryzae infection in immunocompetent mice. Methods: C57Bl/6, BALB/c and Swiss wild-type mice were intravenously infected with R. oryzae; the parameters of infection and immune response were determined. Transcriptional signature of Th17 immune response and infection in Il17ra-/- mice were also evaluated. Results: All mouse strains showed an initial spread of R. oryzae in the target tissues; however, after 30 days, C57Bl/6 and BALB/c mice showed an effective fungal clearance associated with specific production of IL-17 and IL-2. We also observed that 60% of Il17ra-/- mice succumbed to infection within 16 days. Conclusion: This study has established an immunocompetent model for disseminated mucormycosis and highlighted the role of IL-17 signaling in immunity against R. oryzae.