Published in
Oxford University Press, Clinical Infectious Diseases, 11(72), p. 2029-2031, 2020
DOI: 10.1093/cid/ciaa1015
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Circulating Pregenomic Hepatitis B Virus RNA Is Primarily Full-length in Chronic Hepatitis B Patients Undergoing Nucleos(t)ide Analogue Therapy
Journal article published in 2020 by
Mark Anderson,
Jeffery Gersch,
Ka-Cheung Luk,
George Dawson,
Ivana Carey 
,
Kosh Agarwal,
Pir Shah,
Geoffrey Dusheiko,
Daryl Lau,
Gavin Cloherty
,
Kosh Agarwal,
Pir Shah,
Geoffrey Dusheiko,
Daryl Lau,
Gavin Cloherty
This paper was not found in any repository, but could be made available legally by the author.
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Abstract
Abstract Hepatitis B virus RNA is detectable in the serum of infected patients; however, the RNA species has been questioned. We tested 1827 specimens using a quantitative dual-target quantitative polymerase chain reaction assay and determined that full-length pregenomic RNA is the primary source. These results clarify the major identity of circulating HBV RNA species.