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Oxford University Press, Open Forum Infectious Diseases, 8(7), 2020

DOI: 10.1093/ofid/ofaa300

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Increasing Drug Resistance Among Persons with Tuberculosis in Massachusetts, 2009-2018

Journal article published in 2020 by Jared J. Eddy ORCID, Kavita M. Gadani, Andrew Tibbs, John Bernardo ORCID, Jennifer Cochran, Laura F. White ORCID, C. Robert Horsburgh ORCID, Karen R. Jacobson ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract We examined Massachusetts tuberculosis surveillance data from to 2009 to 2018. Of 1533 culture-confirmed cases, 190 (12.4%) demonstrated resistance to isoniazid including 32 (2.1%) with rifampin resistance. In multivariable analysis, isoniazid resistance increased significantly over time (per-year odds ratio = 1.07, 95% confidence interval = 1.01–1.13, P = .018) and was associated with younger age, foreign birth, and prior tuberculosis treatment.