The accurate measurement of physical activity (PA) in adults with depression is critical to identify important health consequences and determinants of this behavior. This study aimed to propose a protocol for a systematic review investigating the recommended dose of PA in the treatment of depression in adults aged 18 to 65 years. Additionally, we intend to examine the effect of PA interventions on the prevalence of depression. This protocol for a systematic review has been submitted in the Prospective International Register submitted in Register of Systematic Reviews of PROSPERO and is being prepared in accordance with the Declaration of Preferential Items for Systematic Reviews and Meta-Analysis Protocols. This protocol provides justification and planned methods for a systematic review to examine the respective dose of PA and how interventions have a beneficial impact on adults with depression.