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Beilstein-Institut, Beilstein Journal of Organic Chemistry, (16), p. 1706-1712, 2020

DOI: 10.3762/bjoc.16.142

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Microwave-assisted efficient one-pot synthesis of N<sup>2</sup>-(tetrazol-5-yl)-6-aryl/heteroaryl-5,6-dihydro-1,3,5-triazine-2,4-diamines

Journal article published in 2020 by Moustafa Sherief Moustafa ORCID, Ramadan Ahmed Mekheimer ORCID, Saleh Mohammed Al-Mousawi, Mohamed Abd-Elmonem ORCID, Hesham El-Zorba, Afaf Mohamed Abdel Hameed, Tahany Mahmoud Mohamed, Kamal Usef Sadek ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

An efficient one-pot synthesis of N2-(tetrazol-5-yl)-6-aryl/heteroaryl-1,3,5-triazine-2,4-diamine derivatives was developed by reacting 5-amino-1,2,3,4-tetrazole with aromatic aldehydes and cyanamide in pyridine under controlled microwave heating with high yields. X-ray crystallography confirmed the structure of the obtained products.