Social isolation and physical distancing measures, such as quarantine, local confinement, lockdown and isolation, aim to slow the spread of the coronavirus disease (COVID-19). This condition is necessary; however, sedentary behaviors are stimulated. The aim of this manuscript is to propose simple home-based exercises that everyone, considering their individual limitations, could perform. Moreover, individuals might monitor their performance daily. Feasible and useful home-based exercise strategies, to counter-balance the negative impact of the sedentary lifestyle during confinement, will stimulate the population to perform some exercises wherever possible. For this, home-based exercises were proposed based on physical tests, such as a stair climb test, balance test, single-leg-stance-test, gait speed, five-chair stand, free walking, free run, six-minute walk test, timed up and go, sit-and-reach, fingertip-to-floor test, and free physical exercises. It is important to consider that when the individual is performing the test, physical exercise is also being done. In conclusion, several exercises that consider the clinical conditions of the individuals and can reduce their sedentary behavior, considering COVID-19 confinement, are suggested to improve the population’s quality of life.