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Korean Pediatric Society, Clinical and Experimental Pediatrics, 5(64), p. 208-222, 2021

DOI: 10.3345/cep.2020.00633

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Understanding the genetics of systemic lupus erythematosus using Bayesian statistics and gene network analysis

This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The publication of genetic epidemiology meta-analyses has increased rapidly, but it has been suggested that many of the statistically significant results are false positive. In addition, most such meta-analyses have been redundant, duplicate, and erroneous, leading to research waste. In addition, since most claimed candidate gene associations were false-positives, correctly interpreting the published results is important. In this review, we emphasize the importance of interpreting the results of genetic epidemiology meta-analyses using Bayesian statistics and gene network analysis, which could be applied in other diseases.