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American Association for the Advancement of Science, Science Advances, 29(6), 2020

DOI: 10.1126/sciadv.aba1773

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Single C-to-T substitution using engineered APOBEC3G-nCas9 base editors with minimum genome- and transcriptome-wide off-target effects

Journal article published in 2020 by Sangsin Lee ORCID, Ning Ding ORCID, Yidi Sun ORCID, Tanglong Yuan ORCID, Jing Li, Qichen Yuan, Lizhong Liu ORCID, Jie Yang ORCID, Qian Wang ORCID, Anatoly B. Kolomeisky ORCID, Isaac B. Hilton ORCID, Erwei Zuo ORCID, Xue Gao ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Engineered base editors convert the second nucleotide C to T in the context of 5′-CC-3′ with high precision and targeting fidelity.