This problematic article considers the role of the psychosocial factors on neurotic disorders manifestation in metropolis citizens. The specific factors impact on the neurotic disorders incidence is analyzed. The role of the metropolis psychological and social influence on the ones global functioning is represented. The article describes the specific of the development and course of the neurasthenic, histrionic, obsessive anxiety disorders and non-chemical addictions.Problems highlighted in this article belongs to the main modern life challenges, taking by WHO as the global problems, that were included in the targeted Healthy Cities program also aimed to treat and prevent metropolis mental disorders.