ABSTRACT In semiarid areas, the scarcity of water with low salt concentration associated with irregular precipitation becomes a limiting factor to ensure agricultural production. In this context, the objective of this study was to evaluate the growth and production of sesame genotypes under different strategies of use of saline water. The experiment was conducted under protected environment conditions, using a randomized block design in a 6 x 2 factorial scheme, and the treatments consisted of six strategies for the use of saline water in the different stages of plant development (SE = irrigation with low-salinity water throughout the cultivation cycle; VE, FL, FR, VE/FL and VE/FR - respectively, irrigation with high-salinity water at the vegetative stage, flowering, fruiting, vegetative/flowering and vegetative/fruiting) and two sesame genotypes (BRS Seda and BRS Anahí), with 4 replicates. Irrigation with high-salinity water (ECw = 2.7 dS m-1) during the vegetative, flowering and fruiting stages did not compromise sesame production. There were reductions in sesame growth when irrigation with high-salinity water was continuously applied at the vegetative/flowering stages and in sesame production when it was applied during the vegetative/flowering and vegetative/fruiting stages. The greater growth of BRS Seda sesame plants resulted in an increase in the total number of fruits and in the total seed weight.