This study reports the catalytic properties of Ag nanoparticles dispersed on mixed ionic and electronic conducting layers of LSCF (La0.6Sr0.4Co0.2Fe0.8O3) for propene combustion. A commercial and a synthesized LSCF powder were deposited by screen-printing or spin-coating on dense yttria-stabilized zirconia (YSZ) substrates, an oxygen ion conductor. Equal loadings (50 µg) of Ag nanoparticles were dispersed via drop-casting on the LSCF layers. Electrochemical and catalytic properties have been investigated up to 300 °C with and without Ag in a propene/oxygen feed. The Ag nanoparticles do not influence the electrochemical reduction of oxygen, suggesting that the rate-determining step is the charge transfer at the triple phase boundaries YSZ/LSCF/gas. The anodic electrochemical performances correlate well with the catalytic activity for propene oxidation. This suggests that the diffusion of promoting oxygen ions from YSZ via LSCF grains can take place toward Ag nanoparticles and promote their catalytic activity. The best specific catalytic activity, achieved for a LSCF catalytic layer prepared by screen-printing from the commercial powder, is 800 times higher than that of a pure Ag screen-printed film.