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American Physiological Society, American Journal of Physiology - Heart and Circulatory Physiology, 2(319), p. H443-H455, 2020

DOI: 10.1152/ajpheart.00176.2020

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The Role of Endothelial Autocrine NRG1/ERBB4 Signaling in Cardiac Remodeling

Journal article published in 2020 by Lindsey Dugaucquier ORCID, Eline Feyen ORCID, Ligia Mateiu, Tine Anne Marie Josephine Bruyns, Gilles W. De Keulenaer, Vincent Fm M. Segers ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

The role of NRG1/ERBB signaling in endothelial cells is not completely understood. Our study contributes to the understanding of spatiotemporal heterogeneity of myocardial autocrine and paracrine responses following cardiac injury and shows a role of endothelial autocrine NRG1/ERBB4 signaling in the modulation of hypertrophic and fibrotic responses during early cardiac remodeling.