American Physiological Society, Journal of Applied Physiology, 3(129), p. 583-590, 2020
DOI: 10.1152/japplphysiol.00105.2020
Full text: Unavailable
A head-on comparison between imaging and multiple breath washout in supine smokers shows that computer tomography-measured unequal local lung expansion accounts for 50% or less of smoking-induced increase in ventilation heterogeneity. The contributions from unequal lung expansion and peripheral structure to the two main washout indices also explain their respective association with parametric response mapping indices.