Background: Repairing a restoration is a more advantageous and less invasive alternative to its total makeover. The aim of this study was to analyze the effects of chemical and mechanical surface treatments aimed at increasing the roughness of a supra-nano composite resin. Methods: 27 cylindrical blocks of microhybrid composite were made. The samples were randomly divided into nine groups (n = 3). The samples’ surface was treated differently per each group: acid etching (35% H3PO4, 30 s and 60 s), diamond bur milling, sandblasting and the combination of mechanical treatment and acid etching. The samples’ surface was observed by a scanning electron microscope (SEM) and a confocal microscope for observational study, and surface roughness (Ra) was recorded for quantitative analysis. Results: The images of the samples sandblasted with Al2O3 showed the greatest irregularity and the highest number of microcavities. The surfaces roughened by diamond bur showed evident parallel streaks and sporadic superficial microcavities. No significant roughness differences were recorded between other groups. The difference in roughness between the control group, diamond bur milled group and sandblasted group was statistically significant. (p < 0.01). Comparison between the diamond bur milled group and the sandblasted group was also significant (p < 0.01). Conclusion: According to our results, sandblasting is the best treatment to increase the surface roughness of a supra-nano composite.