Abstract Cavitating flow is extremely complex in axial and mixed flow pumps, resulting in several adverse effects on pump performance. In this paper, the tip leakage vortex (TLV) cavitation patterns in an axial flow pump model were studied based on high-speed photography and transient pressure measurements. The TLV cavitation morphology and transient development of the induced suction-side-perpendicular cavitating vortices (SSPCVs) were investigated at multi-operating conditions. The time-domain of the transient pressure was employed to clarify the relationship between the tip cavitation and the pressure field. The results showed that cavitation inception occurred earlier with an unstable TLV cavitation shape at part-load conditions. Cavitation was more intense with a decrease of the cavitation number, presenting a larger area of triangular cavitation with the shedding of SSPCV. The inception of SSPCV was attributed to the tail of the shedding cavitation cloud originally attached to the suction surface (SS) of the blade, moving in the direction of the adjacent blade perpendicular to the SS, resulting in a flow blockage. With a further decrease in pressure, the SSPCVs grew in size and strength, accompanied by a rapid degradation in performance of the pump. The cavitation images and the corresponding circumferential pressure distributions showed that the lowest pressure point coincided with the SS corner. After this position, the pressure fluctuated as the cavitation intensity changed. The transient characteristics of SSPCV are a basis for revealing the instability mechanism of its evolution in the axial flow pump.