Acute limb ischemia in a patient with pre-fibrotic myelofibrosis complicated by heparin-induced thrombocytopenia and thrombosis – case report and systematic review of dabigatran use
Journal article published in 2020 by
Marina Di Pilla,
Stefano Barco 
,
Clara Sacco,
Giovanni Barosi,
Corrado Lodigiani
,
Clara Sacco,
Giovanni Barosi,
Corrado Lodigiani
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Abstract
Summary: A 49-year-old man was diagnosed with pre-fibrotic myelofibrosis after acute left lower-limb ischemia requiring amputation and portal vein thrombosis. After surgery he developed heparin-induced thrombocytopenia (HIT) with venous thromboembolism, successfully treated with argatroban followed by dabigatran. Our systematic review of the literature supports the use of dabigatran for suspected HIT.