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Elsevier, Journal of Hepatology, 6(36), p. 805-811, 2002

DOI: 10.1016/s0168-8278(02)00060-0

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Oxidative stress in chronic hepatitis C: not just a feature of late stage disease.

Journal article published in 2002 by Sanjiv K. Jain, Philip W. Pemberton, Alexander Smith, Raymond F. T. McMahon ORCID, Peter C. Burrows, Ali Aboutwerat, Thomas W. Warnes
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

BACKGROUND/AIMS: Chronic hepatitis C infection is a major world-wide problem, frequently progressing to cirrhosis, liver failure or hepatoma. The pathological mechanisms of disease progression are unclear but oxidant stress may play a role.METHODS: Markers of lipid peroxidation, antioxidant status, hepatic fibrogenesis and liver function were measured in blood or urine from 42 chronic hepatitis C patients. Fibrosis was graded histologically in a subgroup of 33 patients.RESULTS: The lipid peroxidation marker 8-isoprostane and the ratio of oxidized to reduced glutathione were significantly elevated (P