For the X-ray beam transport systems, the problem of potential damage to the equipment by mis-steered photon beam emerged with advent of powerful X-ray FELs. In particular high repetition rate machines as European XFEL, where not only focused beam can produce ablation, but even unfocused beam can melt the beamline components while machine operates in multibunch mode, demand for implementation of equipment protection. Here we report on development of photon beam loss monitors at European XFEL facility. The photon beam loss monitors will react on the mis-steered photon beam and interface the machine protection system. The prototype comprises the vacuum chamber with fluorescence crystals positioned outside the photon beampath. The fast sub-hundred ns fluorescence induced by mis-steered beam can be detected by photomultiplier tube allowing for intra-train reaction of machine protection system. First tests have been carried out at FLASH and shown the feasibility of detection based on PMT-detected fluorescence. In addition to efficient YAG:Ce crystal, the robust low-Z material as CVD microcrystalline diamonds has shown a potential to be used as fluorescence crystals.