Experience developing multidisciplinary bachelor’s and master’s curricula involving intertwined chemistry, informatics, and librarianship–editorship skills is described. The bachelor’s curriculum was created in close cooperation of academic staff, library staff, and the publishing house staff (Institute of Chemical Technology Prague: a sole publisher of chemical literature in Czech Republic), with the aim to educate a new generation of information retrieval and e-publishing professionals in the science–technology–medicine (STM) field. This cooperation together with a set of specifically tailored courses gave students the insights into real-world issues of STM publishing. The master’s curriculum, heavily relying on the bachelor’s stage, inclines towards cheminformatics and deepens software engineering skills. Successes, pitfalls, and failures are described, together with proposed changes and future directions.