Background: The nursing process is a systemic approach to patient care and enables nurses in health care institutions to render comprehensive care aimed at achieving quality. During the implementation of the nursing process, nurses are faced with multiple traits that hinder effective implementation. The nursing process has been widely recommended as an approach that guides nurses towards quality nursing care, thus, non-adherence is associated with substandard patient care. Objective: The objective was to explore and describe the practices of nurses when implementing the nursing process at a selected public hospital in Limpopo province, South Africa. Methods: A qualitative, explorative-descriptive approach research method was used to collect data. A non-probability purposive sampling method was used to initially select 5 professional nurses to participate in the study and later on, more data was collected from 3 unit managers. Data was collected using a semi-structured interview until data saturation, and data was analyzed using the Tesch’s open coding method of data analysis, where themes and sub-themes were developed. Measures to ensure trustworthiness were all adhered to the study. Results: The results explained the practices of nurses when implementing the nursing process and the challenges encountered during the implementation of the nursing process. Conclusion: The study findings indicated a need for continuous in-service training, provision of adequate resources and development of a formal training program.