Published in
American Association for the Advancement of Science, Science Advances, 26(6), 2020
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Impact of mRNA chemistry and manufacturing process on innate immune activation
Journal article published in 2020 by
Jennifer Nelson 
,
Elizabeth W. Sorensen ,
Shrutika Mintri,
Amy E. Rabideau ,
Wei Zheng ,
Gilles Besin,
Nikhil Khatwani,
Stephen V. Su,
Edward J. Miracco ,
William J. Issa,
Stephen Hoge ,
Matthew G. Stanton,
John L. Joyal
,
Elizabeth W. Sorensen ,
Shrutika Mintri,
Amy E. Rabideau ,
Wei Zheng ,
Gilles Besin,
Nikhil Khatwani,
Stephen V. Su,
Edward J. Miracco ,
William J. Issa,
Stephen Hoge ,
Matthew G. Stanton,
John L. Joyal
This paper is made freely available by the publisher.
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Abstract
A combination of uridine modification and process optimization minimizes innate immune response to therapeutic mRNA.