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Nature Research, Nature Chemical Biology, 6(4), p. 341-343, 2008

DOI: 10.1038/nchembio.84

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A global assembly line for cyanobactins

Journal article published in 2008 by Mohamed S. Donia, Jacques Ravel ORCID, Eric W. Schmidt
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

More than 100 cyclic peptides harboring heterocyclized residues are known from marine ascidians, sponges and different genera of cyanobacteria. Here, we report an assembly line responsible for the biosynthesis of these diverse peptides, now called cyanobactins, both in symbiotic and free-living cyanobacteria. By comparing five new cyanobactin biosynthetic clusters, we produced the prenylated antitumor preclinical candidate trunkamide in Escherichia coli culture using genetic engineering.