Red cell bound antibodies and transfusion requirements in hospitalized patients with COVID-19
Journal article published in 2020 by
Alessandra Berzuini,
Cristiana Bianco,
Cinzia Paccapelo,
Francesco Bertolini,
Giuliana Gregato,
Alessandra Cattaneo 
,
Elisa Erba,
Alessandra Bandera ,
Andrea Gori,
Giuseppe Lamorte,
Maria Manunta ,
Laura Porretti ,
Nicoletta Revelli,
Francesca Truglio,
Giacomo Grasselli
and other authors.
,
Elisa Erba,
Alessandra Bandera ,
Andrea Gori,
Giuseppe Lamorte,
Maria Manunta ,
Laura Porretti ,
Nicoletta Revelli,
Francesca Truglio,
Giacomo Grasselli
and other authors.
This paper is made freely available by the publisher.
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Abstract
Berzuini et al report the observation that nearly half of patients with COVID-19 tested at their blood center had a positive direct antiglobulin test (DAT). However, eluates did not react with any test cells but did react with red cells from other patients with COVID-19 that were DAT negative. This suggests that COVID-19 may modulate the red cell membrane and present novel antigenic epitopes.