INTRODUCTION: Approximately 20% of patients are not satisfied following Total knee arthroplasty (TKA). The ability to identify patients at risk of poor outcomes in the early-postoperative period following TKA could inform the development of targeted treatments with the ability to improve outcomes for these patients. This prospective cohort study aimed to identify early post-operative, prognostic factors for patients experiencing dissatisfaction and poor outcomes at 12-months post TKA. METHODS: Patients (n = 185) were recruited from TKA waiting lists at a single site, completed measures of pain intensity, neuropathic pain, anxiety, depression, generic and disease specific health related quality of life (HRQoL), satisfaction and expectations, at discharge from hospital; three weeks post-surgery and again at 1 year. ROC curve analysis identified which variables best predicted patients experiencing dissatisfaction (VAS < 5/10) and poor outcomes (Western Ontario and McMaster Universities Arthritis Index (WOMAC)<40) at 12-months. RESULTS: The strongest prognostic factors for dissatisfaction were low HRQoL (EQ5D3L) at both day of discharge (AUC = 0.812) and three weeks post-surgery (AUC = 0.810), and high pain levels (WOMAC pain sub-scale) at 3-weeks post-TKA (AUC = 0.796). The strongest prognostic factors for poor outcomes were poor function (WOMAC function sub-scale) at three weeks post TKA (AUC = 0.815); low HRQoL (EQ5D3L) at three weeks post-TKA (AUC = 0.783) and high levels of pain (WOMAC pain sub-scale) at 3 weeks post-TKA (AUC = 0782). Anxiety and depression at 3-weeks were also prognostic factors for dissatisfaction (AUC = 0.629 & AUC = 0.686) and poor outcomes (AUC = 0.632 & 0.713) at 12-months. CONCLUSION: This single site cohort study suggests that patients with low HRQoL, high pain levels, poor function, anxiety, and depression in the first three weeks following TKA are at risk of dissatisfaction and poor outcomes at one-year post-surgery.