Abstract Objective: To explore the nursing effect of clinical, surgical nursing on patients with acute appendicitis. Methods: A total of 80 patients with acute appendicitis admitted to our hospital from May2016 to July 2018 were randomly divided into two groups. The patients in the control group received routine nursing. Those in the observation group received clinical, surgical nursing based on that in the control group. After nursing for a period, the nursing effectiveness, incidence of complications. Results: The incidence of postoperative complications in the observation group was 6.67% (4/60), and that in the control group was 21.67 (13/60). The effective nursing rate was 91.67% in the observation group, and that in the control group was 80.00%. Conclusions: The implementation of personalized surgical nursing intervention in the treatment of elderly patients with acute appendicitis can effectively alleviate the adverse emotions of the patients, shorten the time required for anesthesia recovery, reduce the occurrence of various adverse symptoms, with relatively high safety.