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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 9(64), 2020

DOI: 10.1128/aac.00993-20

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Bacteriophage-Antibiotic Combinations for Enterococcus faecium with Varying Bacteriophage and Daptomycin Susceptibilities

Journal article published in 2020 by Taylor Morrisette ORCID, Katherine L. Lev, Razieh Kebriaei, Jacinda C. Abdul-Mutakabbir, Kyle C. Stamper, Sandra Morales, Susan M. Lehman ORCID, Gregory S. Canfield, Breck A. Duerkop ORCID, Cesar A. Arias, Michael J. Rybak ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Concerns regarding increased prevalence of daptomycin (DAP)-resistant strains necessitate novel therapies for Enterococcus faecium infections. Obligately lytic bacteriophages are viruses that target, infect, and kill bacterial cells. Limited studies have evaluated phage-antibiotic combinations against E. faecium . After an initial screen of eight E. faecium strains, three strains with varying DAP/phage susceptibilities were selected for further experiments.