Published in
American Physiological Society, Journal of Applied Physiology, 1(129), p. 124-132, 2020
DOI: 10.1152/japplphysiol.00456.2019
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Neutralizing mitochondrial ROS does not rescue muscle atrophy induced by hindlimb unloading in female mice
Journal article published in 2020 by
Hiroaki Eshima,
Piyarat Siripoksup,
Ziad S. Mahmassani 
,
Jordan M. Johnson ,
Patrick J. Ferrara,
Anthony R. P. Verkerke,
Anahy Salcedo,
Micah J. Drummond ,
Katsuhiko Funai
,
Jordan M. Johnson ,
Patrick J. Ferrara,
Anthony R. P. Verkerke,
Anahy Salcedo,
Micah J. Drummond ,
Katsuhiko Funai
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Abstract
The premise of this study was to examine the efficacy of genetic suppression of mitochondrial reactive oxygen species (ROS) to attenuate disuse-induced muscle atrophy and muscle weakness. Neutralization of mitochondrial ROS by MCAT expression was insufficient to rescue muscle atrophy and muscle weakness.